GLP-2-TZ

GLP-2-TZ is our catalog designation for research-grade tirzepatide, a synthetic 39-amino-acid peptide supplied as a lyophilized powder for laboratory research use only. Every lot is independently assayed by Janoshik Analytical and the Certificate of Analysis is published before the lot is listed for sale.

Compound overview

Tirzepatide is a dual incretin receptor agonist, meaning a single molecule engages two distinct receptor targets: the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor. This dual-agonist architecture distinguishes it structurally and pharmacologically from single-target GLP-1 receptor agonists such as semaglutide.

The peptide backbone is based on the native GIP sequence rather than GLP-1, with substitutions at positions 2 and 13 conferring resistance to enzymatic degradation by dipeptidyl peptidase-4 (DPP-4). A C20 fatty diacid moiety is conjugated via a linker at position 20, promoting reversible albumin binding. This acylation strategy substantially extends circulating half-life in published pharmacokinetic models, which is why tirzepatide appears frequently in research examining sustained receptor engagement.

Research context

Tirzepatide is widely referenced in the incretin biology literature as a tool compound for investigating co-agonism. Researchers studying receptor crosstalk, biased signaling, beta-cell physiology, and comparative incretin pharmacology commonly use dual agonists to separate GIP-mediated from GLP-1-mediated effects in cell and tissue models. Published work has examined cAMP accumulation, beta-arrestin recruitment, and receptor internalization kinetics across both receptor populations.

This material is supplied strictly as a research chemical for use by qualified investigators in a controlled laboratory setting. It is not a drug, not a dietary supplement, and is not intended for diagnostic, therapeutic, or human use of any kind.

Analytical verification

Every lot is tested by Janoshik Analytical, an independent third-party laboratory, before it is offered. Testing covers identity and purity by HPLC, with mass spectrometry confirming molecular weight against the expected value for the tirzepatide sequence.

The lot number printed on your vial label matches a specific Certificate of Analysis in our COA Library. We publish the full report rather than a summary figure, so you can review the chromatogram, the integration, and the reported purity yourself. If you are unfamiliar with reading these reports, our guide on how to actually read a Janoshik COA walks through what each section means and which numbers matter.

Specifications

• Compound: Tirzepatide (catalog designation GLP-2-TZ)
• Form: Lyophilized powder, sealed vial
• Molecular formula: C225H348N48O68
• Molecular weight: approximately 4813.5 g/mol
• Purity: See the published COA for the specific lot
• Testing: HPLC and MS by Janoshik Analytical
• Available sizes: 10mg per vial

Handling and storage

Lyophilized peptide should be stored sealed and protected from light. Short-term storage at 2 to 8 degrees Celsius is appropriate for material in active use; long-term storage at -20 degrees Celsius or below preserves stability over extended periods. Allow sealed vials to equilibrate to room temperature before opening to limit condensation, which introduces moisture and accelerates degradation.

Repeated freeze-thaw cycling is the most common avoidable cause of degradation in laboratory settings. Aliquoting reconstituted material into single-use volumes avoids subjecting the full quantity to repeated temperature transitions. Our bacteriostatic water is stocked for laboratories that need reconstitution diluent.

Related research reading

For background on the dual-receptor mechanism, see our article on tirzepatide and dual GIP/GLP-1 receptor agonism. For comparison against single-target agonists, see semaglutide and GLP-1 receptor signaling.

For laboratory research use only. Not for human or veterinary consumption. Not for diagnostic or therapeutic use.